BDBM427067 US10544132, Example 20::US11236047, Example 20::US20230338337, Example 20

SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(cc1)C#C)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=LTEBUYNLVXWZOS-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 427067   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427067(US10544132, Example 20 | US11236047, Example 20 | ...)
Affinity DataIC50: 11nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427067(US10544132, Example 20 | US11236047, Example 20 | ...)
Affinity DataIC50: 11nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427067(US10544132, Example 20 | US11236047, Example 20 | ...)
Affinity DataIC50: 26nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427067(US10544132, Example 20 | US11236047, Example 20 | ...)
Affinity DataIC50: 11nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)