BDBM426226 5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyrazolo[1,5-::US10513523, Example 166

SMILES OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1

InChI Key InChIKey=UWIJVELUZWBFEU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 426226   

TargetGlutamate receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM426226(US10513523, Example 166 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 0.200nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2C8(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426226(US10513523, Example 166 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426226(US10513523, Example 166 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 0.200nMAssay Description:Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM426226(US10513523, Example 166 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed