BDBM412745 N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 10

SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F

InChI Key InChIKey=KNTWBIUWHSYQJE-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 412745   

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
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TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
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TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataIC50: 0.560nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
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In DepthDetails
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails
US Patent

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM412745(US10399987, Example 10 | N-(3-fluoropyridin-4-yl)-...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails Article
PubMed