BDBM405588 US10351547, Compound 2-2::US10464918, Compound A::US10597377, Compound 2-2

SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1

InChI Key InChIKey=GHILNKWBALQPDP-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 405588   

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50: <10nMAssay Description:Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC # CCL-61) stably expressing the human SSTR2 are plated in each well of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSomatostatin receptor type 2(Human)
Crinetics Pharmaceuticals

US Patent
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSomatostatin receptor type 2(Rat)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at rat SST2 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSomatostatin receptor type 2(Dog)
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM405588(US10351547, Compound 2-2 | US10464918, Compound A ...)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at dog SST2 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMed