BDBM389289 US9951027, 2-76-1

SMILES CC(C)c1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(O)=O)cc1

InChI Key InChIKey=GWMNDWCQEWDFPA-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 389289   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM389289(US9951027, 2-76-1)
Affinity DataIC50: 30nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)