BDBM376145 N-(3-methoxybenzyl)-5H- chromeno[3,4-c]pyridine-8- carboxamide::US9914740, I-27

SMILES COc1cccc(CNC(=O)c2ccc-3c(OCc4cnccc-34)c2)c1

InChI Key InChIKey=SIKMVWPMDNIKAY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376145   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376145(US9914740, I-27 | N-(3-methoxybenzyl)-5H- chromeno...)
Affinity DataIC50: 6.32nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376145(US9914740, I-27 | N-(3-methoxybenzyl)-5H- chromeno...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376145(US9914740, I-27 | N-(3-methoxybenzyl)-5H- chromeno...)
Affinity DataIC50: 33nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed