BDBM36894 5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide::MLS000038106::SMR000040050::cid_659101

SMILES O=S1(=O)Nc2c(ccc3cccnc23)-c2ccccc12

InChI Key InChIKey=CYSOFAOLQAYKGU-UHFFFAOYSA-N

Data  8 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 36894   

TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  3.22E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50: >9.51E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  3.95E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 3.80E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 4.43E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 4.72E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 5.46E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetMatrix metalloproteinase-14 [1-36](Human)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  2.46E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetIntegrin alpha-4(Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  1.99E+4nMAssay Description:Assay Support: 1 X01 MH077638-01 MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin PI: SKLAR, LARRY A University of New Mexico Assay Overview...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetKappa-type opioid receptor(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 1.30E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHeat shock factor protein 1(Mouse)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  2.76E+3nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetToll-like receptor 9(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 4.97E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 4.97E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetNF-kappa-B inhibitor alpha(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  2.20E+3nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription factor p65(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNF-kappa-B inhibitor alpha(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM36894(SMR000040050 | cid_659101 | MLS000038106 | 5H-quin...)
Affinity DataEC50:  2.60E+3nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed