BDBM36024 (R)-(-)-phenylephrine::PHENYLEPHRINE::Phenylephrine,(-)

SMILES C[NH2+]C[C@H](O)c1cccc(O)c1

InChI Key InChIKey=SONNWYBIRXJNDC-UHFFFAOYSA-O

Data  18 KI  4 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 36024   

TargetAlpha-1A adrenergic receptor(Rat)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-1A adrenergic receptor(Dog)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  213nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  340nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  370nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Dog)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  901nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  1.25E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  1.44E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  1.47E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  6.10E+3nMAssay Description:Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  6.40E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Duke University

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
National Children'S Medical Research Center

Curated by PDSP Ki Database
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
Affinity DataKi:  1.30E+4nMAssay Description:Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 4 hits for monomerid = 36024   

HostPNGBDBM4((1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23...)
Nist

GuestPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
ITC DataΔG°: -0.836kcal/mole −TΔS°: 7.19kcal/mole ΔH°: -8.12kcal/mole logk: 4.07
pH: 6.9 T: 24.85°C 
In DepthDetails
HostPNGBDBM4((1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23...)
Nist

GuestPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
ITC DataΔG°: -0.764kcal/mole −TΔS°: 5.25kcal/mole ΔH°: -5.97kcal/mole logk: 3.63
pH: 5.0 T: 24.85°C 
In DepthDetails
HostPNGBDBM11(betadex | beta-cyclodextrin)
Nist

GuestPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
ITC DataΔG°: -2.27kcal/mole −TΔS°: 2.36kcal/mole ΔH°: -4.64kcal/mole logk: 46.6
pH: 6.9 T: 24.85°C 
In DepthDetails
HostPNGBDBM11(betadex | beta-cyclodextrin)
Nist

GuestPNGBDBM36024(PHENYLEPHRINE | Phenylephrine,(-) | (R)-(-)-phenyl...)
ITC DataΔG°: -2.17kcal/mole −TΔS°: 3.06kcal/mole ΔH°: -5.23kcal/mole logk: 39.3
pH: 5.0 T: 24.85°C 
In DepthDetails