BDBM344408 US9783500, Compound 10::US9783500, Compound 4

SMILES CN(C)Cc1cccc(OCc2ccc3ccc(N)nc3c2)c1

InChI Key InChIKey=NTASSNARMLLQTN-UHFFFAOYSA-N

Data  18 KI

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 344408   

TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  21nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

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TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  21nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  33nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

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TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  39nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  58nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetNitric oxide synthase, brain(Rat)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  179nMAssay Description:Inhibition of wild type recombinant rat nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  295nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidPDBSimilars

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PDB3D Structure (crystal)
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TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  295nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

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PDB3D Structure (crystal)
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TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  295nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

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PDB3D Structure (crystal)
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TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  855nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

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Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetNitric oxide synthase, inducible(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  2.08E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNitric oxide synthase, brain(Mouse)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  5.75E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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PDB3D Structure (crystal)
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TargetNitric oxide synthase, inducible(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  6.66E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNitric oxide synthase, inducible(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  7.41E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNitric oxide synthase, inducible(Human)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  1.03E+4nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNitric oxide synthase, endothelial(Bovine)
Northwestern University

Curated by ChEMBL

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of recombinant bovine eNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidPDBSimilars

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Copy BDB DOIPubMedPDB3D Structure (crystal)
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TargetNitric oxide synthase, brain(Mouse)
Northwestern University

US Patent

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  2.77E+4nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails
Copy BDB DOIUS Patent
PDB3D Structure (crystal)
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TargetNitric oxide synthase, inducible(Mouse)
Northwestern University

Curated by ChEMBL

LigandBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)Copy SMILESCopy InChI

Affinity DataKi:  6.02E+4nMAssay Description:Inhibition of recombinant murine iNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
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