BDBM340691 1,1,1,3,3,3-hexafluoro-2-(4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)phenyl)propan-2-ol::US9771320, Example 5

SMILES OC(c1ccc(cc1)C1(CCCC1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=BANKSZZTXXTYRE-UHFFFAOYSA-N

Data  1 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340691   

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM340691(US9771320, Example 5 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataIC50: 34nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintilla...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM340691(US9771320, Example 5 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataEC50:  10nMAssay Description:Transactivation of PXR in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM340691(US9771320, Example 5 | 1,1,1,3,3,3-hexafluoro-2-(4...)
Affinity DataEC50:  232nMAssay Description:Inverse agonist activity at GAL4-fused RORgammat LBD (267 to 516 residues) (unknown origin) expressed in human Jurkat cells measured after 18 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed