BDBM339679 US10202339, Compound 124

SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)S(=O)(=O)NC2CC2)c1

InChI Key InChIKey=CCAWRGNYALGPQH-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 339679   

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 60nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant wildtype IDH1 (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using DL-isocitrste as substrate assesse...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using 2OG as substrate assessed as 2...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 23nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM339679(US10202339, Compound 124)
Affinity DataIC50: 190nMAssay Description:Inhibition of wildtype IDH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed