BDBM323432 3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phenyl)Propan-1-Ol::US10188615, Example 169::US10639286, Example 169

SMILES NCCC(O)c1cccc(OCC2CCC(F)(F)CC2)c1

InChI Key InChIKey=SXUQDOSXLJQVRA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 323432   

TargetRetinoid isomerohydrolase(Human)
Acucela

US Patent
LigandPNGBDBM323432(3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phen...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRetinaldehyde-binding protein 1(Human)
Acucela

US Patent
LigandPNGBDBM323432(3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phen...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J Biol. Chem. 274:8577-85 (1999).More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRetinoid isomerohydrolase(Bovine)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM323432(3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phen...)
Affinity DataIC50: 103nMAssay Description:Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoid isomerohydrolase(Bovine)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM323432(3-Amino-1-(3-((4,4-Difluorocyclohexyl)Methoxy)Phen...)
Affinity DataIC50: 269nMAssay Description:Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed