BDBM321448 3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethyl-benzamide::US10183009, Example 8

SMILES CN(C)C(=O)c1cccc(c1)-c1cn(CCC=C)c(=O)c2[nH]ccc12

InChI Key InChIKey=VNCNIMOILJQAGJ-UHFFFAOYSA-N

Data  24 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 321448   

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPeregrin(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPeregrin(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 110nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails
Copy BDB DOIUS Patent

Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTranscription initiation factor TFIID subunit 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL

LigandBDBM321448(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)Copy SMILESCopy InChI

Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In DepthDetails Article
Copy BDB DOIPubMed
Copy reaction URL