BDBM317744 US11337976, Compound P-0240::US20230277534, Compound P-0240::US9624213, Compound P-0240
SMILES CCN(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2cnc(nc2)C2CC2)c1F
InChI Key InChIKey=DKNZQPXIIHLUHU-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 317744
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:For example, the biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, where inhibit...More data for this Ligand-Target Pair