BDBM299256 6-(2-fluoro-4-pyridyl)pyrido[3,2-d]pyrimidin-4-amine::US9592235, Example 1::US9855269, Compound 154

SMILES Nc1ncnc2ccc(nc12)-c1ccnc(F)c1

InChI Key InChIKey=CLODUYRNZMIONW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 299256   

LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 11.5nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 11.5nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMisshapen-like kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 199nMAssay Description:Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMisshapen-like kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299256(US9592235, Example 1 | 6-(2-fluoro-4-pyridyl)pyrid...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed