BDBM281119 US10022354, Example 59

SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)cn1

InChI Key InChIKey=JFPBFPWCRUXYRC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 281119   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281119(US10022354, Example 59)
Affinity DataIC50: 0.740nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281119(US10022354, Example 59)
Affinity DataIC50: 727nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed