BDBM26984 BDBM50486225::CHEMBL1644697::CN(-1)::cyanide::iminomethanide

SMILES [C-]#N

InChI Key InChIKey=XFXPMWWXUTWYJX-UHFFFAOYSA-N

Data  40 KI  2 IC50

PDB links: 191 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 26984   

TargetPolyphenol oxidase 2(White button mushroom)
University of California

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of Agaricus bisporus (mushroom) tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldehyde oxidase 1(Rabbit)
University of California

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosolMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nM ΔG°:  -8.45kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMAssay Description:Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMAssay Description:Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  500nM ΔG°:  -8.45kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 15 [19-324](Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  9.40E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nM ΔG°:  -6.30kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  2.00E+4nM ΔG°:  -6.30kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Vibrio cholerae serotype O1 (strain ATCC 39315 / E...)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  3.30E+4nM ΔG°:  -6.01kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Helicobacter pylori)
Universit�� Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  5.40E+5nM ΔG°:  -4.45kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  7.70E+5nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto Di Biochimica Delle Proteine-Cnr

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto Di Biochimica Delle Proteine-Cnr

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto Di Biochimica Delle Proteine-Cnr

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibitory constant against Zn-Cam (Methanosarcina thermophila)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-carbonic anhydrase(Helicobacter pylori)
Universit�� Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  7.60E+5nM ΔG°:  -4.25kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  6.30E+5nMAssay Description:Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Florida

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  5.30E+5nMpH: 8.3Assay Description:Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-carbonic anhydrase(Helicobacter pylori (strain G27))
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  7.60E+5nM ΔG°:  -4.18kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto Di Biochimica Delle Proteine-Cnr

Curated by ChEMBL
LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma carbonic anhydrase family protein(Vibrio cholerae)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  8.40E+6nM ΔG°:  -2.78kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae recombinant carbonic anhydrase gamma expressed in Escherichia coli DE3 cells preincubated for 15 mins by stopped-flow C...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Vibrio cholerae)
Universita Degli Studi Di Firenze

LigandPNGBDBM26984(iminomethanide | CN(-1) | cyanide | CHEMBL1644697 ...)
Affinity DataKi:  5.70E+6nM ΔG°:  -3.01kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae carbonic anhydrase beta preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed