BDBM26739 3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate::CHEMBL184238::URB 597::URB-597::URB597::US9187413, 1a (URB597)
SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
InChI Key InChIKey=ROFVXGGUISEHAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 121 hits for monomerid = 26739
Affinity DataIC50: 4.60nMAssay Description:Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 986nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
Affinity DataIC50: 856nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
Affinity DataIC50: 572nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
Affinity DataIC50: 109nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:The assays for compounds described herein are amenable to high throughput screening. Preferred assays thus detect binding of the inhibitor to FAAH or...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of [3H]anandamide binding to fatty acid amide hydrolase of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 0 min followed by substrate addition by ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 30 mins followed by substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 60 mins followed by substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of Wistar rat brain FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of rat FAAH preincubated for 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Sheep)
Fondazione Istituto Italiano Di Tecnologia
Curated by ChEMBL
Fondazione Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Human)
Fondazione Istituto Italiano Di Tecnologia
Curated by ChEMBL
Fondazione Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic aci...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant FAAH expressed in sf21 cells using AMC-AA as substrate preincubated for 15 mins followed by substrate addition measur...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in rat brain membrane using anandamide[ethanolamine-3H] as substrate assessed as reduction in [3H]-ethanolamine production incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human FAAH incubated 1 hr prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of rat FAAH incubated 1 hr prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of rat FAAH incubated 3 hrs prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 9.0Assay Description:Inhibition of FAAH in rat brain membrane at pH 9 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 141nMpH: 7.4Assay Description:Inhibition of FAAH in rat brain membrane at pH 7.4 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of FAAH from rat brain microsomes by RP-HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarinMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarinMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant FAAH expressed in Escherichia coli using [3H]AEA substrate incubated at 37 degC for 10 mins by liquid scintillation c...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of rat brain membrane FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat intact neuron FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of Sprague-Dawley rat brain microsome FAAH assessed as reduction in 4-pyren-1-ylbutanoic acid release after 60 mins by reverse phase HPLC-...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of mouse FAAH isolated from brain homogenate using [3H-ethanolamine]AEA as substrate incubated for 20 mins prior to substrate addition mea...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant FAAH expressed in Escherichia coli assessed as hydrolysis of [3H]-AEAMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...More data for this Ligand-Target Pair
Affinity DataIC50: 166nMAssay Description:Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic ac...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataEC50: 2.45E+4nMAssay Description:Agonist activity at GDH-tagged human TRPA1 receptor expressed in HEK293F cells assessed as increase in intracellular Ca2+ concentration by FLIPR assa...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.57nMAssay Description:Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataEC50: 2.45E+4nMAssay Description:Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair