BDBM26673 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile::CHEMBL391586::pyridone-based compound, 1

SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1

InChI Key InChIKey=SVSYJTYGPLVUOZ-UHFFFAOYSA-N

Data  4 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26673   

TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBaculoviral IAP repeat-containing protein 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBaculoviral IAP repeat-containing protein 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataKd:  5.70E+3nMAssay Description:Inhibition of survivinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Valeant Pharmaceuticals Research and Development

LigandPNGBDBM26673(CHEMBL391586 | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4...)
Affinity DataIC50: 50nMAssay Description:Competitive inhibition of PIM1 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)