BDBM255338 US9481682, 116::US9481682, 88

SMILES COc1cc(ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F

InChI Key InChIKey=OMIQRSKHABIPRH-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 255338   

TargetTyrosine-protein kinase FRK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 154nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 54nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 102nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 67nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Srms(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 16nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 71nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 84nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 162nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 26nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 0.190nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 64nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 160nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 227nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 19nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 101nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 30nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 17nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) expressed in baculovirus infected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-NH2 peptide as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255338(US9481682, 88 | US9481682, 116)
Affinity DataIC50: 0.220nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In DepthDetails
US Patent