BDBM25284 (1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phenyl]phenyl}-1-phosphonoethyl)phosphonic acid::BPH-675::bisphosphonate, 6
SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O
InChI Key InChIKey=MZVWVRVNMXTDAK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 25284
Affinity DataIC50: 2.69E+3nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of California San Diego
University of California San Diego
Affinity DataIC50: 8.20E+3nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry
Curated by ChEMBL
Institute of Biological Chemistry
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry
Curated by ChEMBL
Institute of Biological Chemistry
Curated by ChEMBL
Affinity DataKi: 80nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair