BDBM24627 1H-indazole::Indazole, 5::Indazole, 6

SMILES c1n[nH]c2ccccc12

InChI Key InChIKey=BAXOFTOLAUCFNW-UHFFFAOYSA-N

Data  5 IC50  4 Kd

PDB links: 10 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 24627   

LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.85E+5nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA repair and recombination protein RadA(Pyrococcus furiosus)
University of Cambridge

LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataKd:  1.00E+6nMAssay Description:The thermal-shift denaturation assay was performed on an iCycler iQ Real Time Detection System (BioRad) in 96-well iCycler iQ PCR plates sealed with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.78E+5nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataKd:  5.30E+3nMAssay Description:Binding affinity to human HSP90alpha assessed as 2D1H-15N chemical shift perturbation by NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataKd:  8.10E+4nMAssay Description:Binding affinity to recombinant ferrous state of IDO1 (unknown origin) expressed in Escherichia coli assessed as dissociation constant incubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Osaka University

Curated by ChEMBL
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to recombinant ferric state of IDO1 (unknown origin) expressed in Escherichia coli assessed as dissociation constant incubated for 3...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed