BDBM23971 (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid::Bestatin::CHEMBL29292::US12054502, Compound Bestatin::Ubenimex
SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
InChI Key InChIKey=VGGGPCQERPFHOB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 144 hits for monomerid = 23971
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of aminopeptidase N (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMpH: 7.2Assay Description:Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 °C. The APN solution was mixed with compounds at v...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:The samples and positive controls were serial diluted to various concentrations: 1280 μg/mL, 320 μg/mL, 80 μg/mL, and 20 μg/mL, 5...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+5nMpH: 8.5 T: 2°CAssay Description:The compound samples were assayed for inhibitory activity against MMP-2 in 96-well microplates using succinylated gelatin as the substrate. The compo...More data for this Ligand-Target Pair
Affinity DataIC50: 2.55E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+5nMAssay Description:Gelatinase A (MMP-2) and TNBS were purchased from Sigma, and the substance was synthesized as described by Vijaykumar et al. The gelatinase, substanc...More data for this Ligand-Target Pair
Affinity DataIC50: 6.25E+3nMpH: 7.2Assay Description:IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P...More data for this Ligand-Target Pair
Affinity DataIC50: 3.24E+5nMAssay Description:Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP2 (unknown origin) using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of microsomal neural aminopeptidase in pig kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilideMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of pig kidney aminopeptidase NMore data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of pig kidney microsomes aminopeptidase NMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of pig kidney microsomal APNMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of pig kidney microsomal Aminopeptidase NMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of aminopeptidase N in pig kidney microsome by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of APN from pig kidney microsomes by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.87E+3nMT: 2°CAssay Description:Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.55E+3nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N using L-Leu-p-nitroanilide substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometerMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of pig kidney microsomal aminopeptidase N after 30 mins by UV-VIS spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of MMP2 after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of porcine kidney microsomal APN using L-Leu-para-nitroanilide as substrate incubated for 2 hrs prior to substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC1/HDAC2 in human HeLa cells nuclear extract preincubated for 5 mins before Boc-Lys (acetyl)-AMC substrate addition for 30 mins by m...More data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of APN in human ES2 cells preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 1 hr by photometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of APN in porcine kidney microsomes preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 30 mins by plate reader ana...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of aminopeptidase B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.62E+5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair