BDBM23446 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one::CHEMBL45068::Phloretin::cid_4788
SMILES Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
InChI Key InChIKey=VGEREEWJJVICBM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 23446
Affinity DataEC50: 2.14E+4nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+7nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of GLUT1 in human H1299 cells assessed as inhibition of 2-deoxy-D-[3H]-glucose uptake incubated for 15 mins prior to 2-deoxy-D-[3H]-glucos...More data for this Ligand-Target Pair
TargetMonocarboxylate transporter 2(Rat)
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetMonocarboxylate transporter 1(Rat)
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.04E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of alpha-chymotrypsin in bovine pancreas using SPpNA as substrate pretreated with enzyme for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 4.96E+5nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase incubated for 10 mins followed by nitrocefin substrate challenge and measured for 5 mins by spectro...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+5nMAssay Description:Inhibition of human DNA topoisomerase 2 catalytic domain-mediated knotted bacteriophage P4Virl dell0 DNA unknotting by agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 8.10E+3nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
TargetSortase B(Staphylococcus aureus subsp. aureus NCTC 8325)
Shandong University of Technology
Curated by ChEMBL
Shandong University of Technology
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of Staphylococcus aureus sortase b transpeptidation expressed in Escherichia coli BL21 (DE3) cells using Fluorescent peptide as substrate ...More data for this Ligand-Target Pair
TargetSolute carrier family 28 member 3(Human)
University of Tennessee Health Sciences Center
Curated by ChEMBL
University of Tennessee Health Sciences Center
Curated by ChEMBL
Affinity DataKi: 3.23E+4nMAssay Description:Binding affinity to human recombinant CNT3 expressed in pig PK15NTD cells assessed as [3H]uridine uptake by beta-scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 8.60E+4nMAssay Description:Binding affinity against Sodium/glucose co-transporter of isolated renal brush border membranes.More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 6 hits for monomerid = 23446
ITC DataΔG°: -8.25kcal/mole −TΔS°: 7.43kcal/mole ΔH°: -15.7kcal/mole logk: 9.00E+5
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C
3D Structure (crystal)ITC DataΔG°: -6.87kcal/mole −TΔS°: -4.88kcal/mole ΔH°: -1.99kcal/mole logk: 9.14E+4
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C
ITC DataΔG°: -8.29kcal/mole −TΔS°: 8.70kcal/mole ΔH°: -17.0kcal/mole logk: 9.75E+5
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C
ITC DataΔG°: -8.74kcal/mole −TΔS°: 10.4kcal/mole ΔH°: -19.2kcal/mole logk: 2.05E+6
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C
ITC DataΔG°: -10.2kcal/mole −TΔS°: 4.89kcal/mole ΔH°: -15.1kcal/mole logk: 2.10E+7
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C
CellTranscriptional Regulator TtgR Mutant R176G(Pseudomonas putida (g-Proteobacteria))
Imperial College
Imperial College
ITC DataΔG°: -6.99kcal/mole −TΔS°: 14.6kcal/mole ΔH°: -21.6kcal/mole logk: 1.09E+5
pH: 7.0 T: 30.00°C
pH: 7.0 T: 30.00°C