BDBM22568 1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}-2-methylguanidine::[3H]tiotidine::tiotidine

SMILES [#6]-[#7]-[#6](-[#7]C#N)=[#7]-[#6]-[#6]-[#16]-[#6]-c1csc(\[#7]=[#6](\[#7])-[#7])n1

InChI Key InChIKey=PJAABXWBSSIBDK-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22568   

TargetHistamine H2 receptor(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi:  32nMAssay Description:Evaluated in vitro for Histamine H2 receptor inhibition using the dimaprit stimulated chronotropic response of the guinea pig atriumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi:  34nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H4 receptor(Human)
Vrije Universiteit Amsterdam

LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi: >1.00E+4nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHrh3 protein(Rat)
Schering-Plough Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22568([3H]tiotidine | 1-cyano-3-{2-[({2-[(diaminomethyli...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed