BDBM223320 KDOAM-25
SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O
InChI Key InChIKey=PNFMVADNCOGWME-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 223320
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
3D Structure (crystal)TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as su...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of KDM5A (M1 to L801 residues) PHD2/3 deletion mutant (unknown origin) demethylation activity preincubated for 10 mins followed by peptide...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of KDM5A (M1 to L801 residues) PHD2/3 deletion mutant (unknown origin) demethylation activity preincubated for 10 mins followed by peptide...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 2.70E+3nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
Affinity DataIC50: 558nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human TET3 catalytic domain (E824 to I1795 residues) expressed in mammalian cells using 5-methylcytosine as substrate preincubated for ...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM5B (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of KDM5C (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of KDM4C (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:KDOAM-25 was tested against a panel of 15 2-OG oxygenases (black text) including a representative from each of the lysine demethylases sub-families.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:KDOAM-25 was tested against a panel of 15 2-OG oxygenases (black text) including a representative from each of the lysine demethylases sub-families.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:MALDI-TOF enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:MALDI-TOF enzymatic assayMore data for this Ligand-Target Pair