BDBM213236 4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine (Compound A)

SMILES NC(=O)c1cc2c(cccc2s1)-c1ccc(s1)C(=O)NCc1ccnc(Cl)c1

InChI Key InChIKey=SKAFXNGFXPGQIG-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 213236   

LigandPNGBDBM213236(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:The PRP4 phosphorylation reaction was performed at room temperature with 15 nM full-length His-tagged PAK4 recombinant protein expressed in Escherich...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM213236(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NanoLuc-fused human DYRK1A expressed in HEK293 cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM213236(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of NanoLuc-fused human DYRK1B expressed in HEK293T cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM213236(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Affinity DataKi:  86nMAssay Description:Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM213236(4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thio...)
Affinity DataKi:  642nMAssay Description:Inhibition of human DYRK1B incubated for 130 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed