BDBM205478 PDD00013907 (1)

SMILES CC(C)(C)NS(=O)(=O)c1ccc2C(=O)c3ccccc3C(=O)c2c1

InChI Key InChIKey=LWNJBYGFPRLQHH-UHFFFAOYSA-N

Data  1 IC50  1 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 205478   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataIC50: 6.00E+4nMpH: 7.4Assay Description:Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataEC50:  8.10E+4nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

LigandPNGBDBM205478(PDD00013907 (1))
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human PARG assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)