BDBM20458 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-isoquinolin-5-ylurea::3-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-1-isoquinolin-5-ylurea::A-778317::Radiolabeled A-778317::[3H] A-778317

SMILES CC(C)(C)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1cccc2cnccc12

InChI Key InChIKey=VPSCJCQPUGKRNC-UHFFFAOYSA-N

Data  1 KI  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20458   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM20458(A-778317 | 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-ind...)
Affinity DataKd:  3.40nMAssay Description:Displacement of [3H]A-778317 from human TRPV1 expressed in CHO cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM20458(A-778317 | 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-ind...)
Affinity DataKi:  7nM ΔG°:  -11.1kcal/mole EC50:  5nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2008
Entry Details Article
PubMed