BDBM195612 GSK467

SMILES O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12

InChI Key InChIKey=ZTYRLXUTLYBVHH-UHFFFAOYSA-N

Data  21 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 195612   

TargetLysine-specific demethylase 4D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 398nMAssay Description:Inhibition of KDM4D (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 26nMAssay Description:Inhibition of KDM5B (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 26nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of KDM5C (unknown origin) measured by by cell imaging assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KDM4C (unknown origin) measured by cell imaging assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human KDM5C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human KDM5C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of N-terminal his-tagged full-length human KDM4C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of N-terminal his-tagged full-length human KDM4C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 631nMAssay Description:Inhibition of KDM4A (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KDM6B (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5A [1-801](Human)
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 24nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 63nMAssay Description:Inhibition of KDM5C catalytic domain (1 -764 aa) (unknown origin) expressed in Sf9 cells using H3K4Me3 peptide as substrate by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full-length EGLN3 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4E(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 501nMAssay Description:Inhibition of KDM4E (unknown origin) by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 501nMAssay Description:Inhibition of N-terminal his-tagged human KDM4C expressed in Escherichia coli BL21(DE3) using trimethylated peptide substrate by RFMS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 3A(Human)
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 3.39E+4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 4C(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 5.10E+3nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5D [1-775](Human)
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 77nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5C [1-765](Human)
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 65nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM195612(GSK467)
Affinity DataIC50: 26nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)