BDBM19460 (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one::8-prenylnaringenin (8-PN)::AIDS095901::CHEMBL376915::YS04::cid_509245

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2-[#6](=O)-[#6]-[#6@H](-[#8]-c12)-c1ccc(-[#8])cc1

InChI Key InChIKey=DBXMWXRCSJKTKC-UHFFFAOYSA-N

Data  10 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 19460   

TargetEstrogen receptor(Human)
Ghent University

LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 57nMpH: 7.6 T: 2°CAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor beta(Human)
Ghent University

LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 68nMpH: 7.6 T: 2°CAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli MV1190 cells preincubated for 10 mins followed by addition of arachidonic acid as ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Naples Federico Ii

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes preincubated for 10 mins followed by addition of arachidonic acid as substrate measured afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor(Human)
Ghent University

LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataEC50:  7nMAssay Description:Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol pho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CaV3.1 expressed in HEK293 cells assessed as suppression of T-current after 10 mins by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CaV3.2 expressed in HEK293 cells assessed as suppression of T-current amplitude after 10 mins by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor beta(Human)
Ghent University

LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataEC50:  5nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor(Human)
Ghent University

LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataEC50:  5nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 10 mins followed by addition of benzylamine...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM19460(CHEMBL376915 | YS04 | (2S)-5,7-dihydroxy-2-(4-hydr...)
Affinity DataIC50: 3.88E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 10 mins followed by addition of kynuramine ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed