BDBM19441 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol::CHEMBL81::Evista::Keoxifene::RALOXIFENE HYDROCHLORIDE::Raloxifene::Raloxifene (7)::Raloxifene, 6::[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone::cid_11071264
SMILES Oc1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1
InChI Key InChIKey=GZUITABIAKMVPG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 134 hits for monomerid = 19441
Affinity DataIC50: 20.6nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
Affinity DataIC50: 557nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nM EC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 260nM EC50: 341nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 22nM EC50: 2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 260nM EC50: 341nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMT: 2°CAssay Description:PLD in vitro enzymatic assay using phospholipase D1(PLD1).More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMT: 2°CAssay Description:PLD in vitro enzymatic assay using phospholipase D2(PLD2).More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311More data for this Ligand-Target Pair
Affinity DataEC50: 8.50E+3nMT: 2°CAssay Description:cell-based assay using human non-small-cell lung cancer cell line, Calu-1More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMT: 2°CAssay Description:cell-based assay using HEK293-gfpPLD2 cell lineMore data for this Ligand-Target Pair
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 1.75E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 1.42E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:In brief, 6 nM purified PldA was incubated with liposomes containing 90 μM 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol), 10 μM...More data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:Antagonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of estrogen-stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [3H]17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:In vitro inhibitory concentration against [3H]17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Binding affinity for Estrogen receptor beta(ER beta) receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Binding to Estrogen receptor- alpha (ER alpha) receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity for Human Estrogen receptor-betaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Binding affinity foor Rat Estrogen receptor-betaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Binding affinity for Rat Estrogen receptor-alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding affinity for Human Estrogen receptor-alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:In vitro binding affinity for estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:In vitro binding affinity for estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding affinity against human estrogen receptor alpha in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]17-beta-estradiol from full length human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity towards human recombinant Estrogen receptor beta was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding affinity towards human recombinant Estrogen receptor alpha was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding potency for human ER betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding potency for human ER betaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity towards human estrogen receptor beta (ERbeta)More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding affinity towards human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]17-beta-estradiol from full length human estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of binding to recombinant human estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of bindign to recombinant human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 18.9nMAssay Description:Inhibition of estrogen receptor betaMore data for this Ligand-Target Pair