BDBM19423 HDAC inhibitor, Compound 1::N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide::N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide (60)::SHI-1:2::benzamide-type inhibitor, 19
SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
InChI Key InChIKey=ABZSPJVXTTUFAA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 19423
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant HDAC3More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using substrate after...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using substrate after 90 m...More data for this Ligand-Target Pair
Affinity DataIC50: 204nMAssay Description:Inhibition of FLAG-tagged HDAC1 S113A mutant (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analy...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of wild-type FLAG-tagged HDAC1 (unknown origin) expressed in Jurkat cells after 2 hrs by Fluor de lys staining-based fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human HDAC1More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human HDAC2More data for this Ligand-Target Pair
Affinity DataIC50: 458nMAssay Description:Inhibition of recombinant human HDAC3More data for this Ligand-Target Pair
Affinity DataKd: 38nMAssay Description:Binding affinity to C-terminal His-tagged human HDAC2 (2 to 488 residues) in transfected in baculovirus infected Sf9 cells assessed as dissociation c...More data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding affinity to human HDAC1 assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
Affinity DataIC50: 10.1nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 56.3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair