BDBM188516 BDOIA383
SMILES COc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1
InChI Key InChIKey=RQFUKBAHMUVXDA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 188516
Affinity DataIC50: 120nMAssay Description:The assay used His-tagged CBP protein, biotinylated histone H4, and detection reagents europium-labeled streptavidin and anti-6His antibody labeled w...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a...More data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
Affinity DataKd: 780nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of BRD4 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CREBBP (unknown origin) by FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to human CBP assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:Binding affinity to human BRD4 bromodomain 1 assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair