BDBM18161 (1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one::(5alpha,17beta)-17-hydroxyandrostan-3-one::BDBM50366473::CHEMBL27769::DHT::Dihydrotestosterone::[3H]DHT
SMILES C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
InChI Key InChIKey=NVKAWKQGWWIWPM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 84 hits for monomerid = 18161
Affinity DataIC50: 7.30E+3nMAssay Description:Binding affinity to PR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Activity at androgen receptor in human Saos2 cells assessed as IL6 repressionMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonistic activity (EC50) against human androgen receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Binding affinity to GR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Ability to inhibit binding of [3H]R-1881 to rat ventral prostrate cytosolic androgen receptor was measured in a radioligand binding assay.More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of hSHBG (human sex hormone binding globulin )More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of rat androgen binding protein (rABP)More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at human AR expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was tested for inhibitory activity against alpha-glucosidase.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor expressed in HEK293 derived FreeStyle293F cells after 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human androgen receptor expressed in COS7 cells assessed as inhibition of DHT-induced luciferase activity after 24 hrs by repo...More data for this Ligand-Target Pair
Affinity DataEC50: 6.20nMAssay Description:Agonist activity at human androgen receptor expressed in COS7 cells assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]Dex from glucocorticoid receptor in Sprague-Dawley rat liver after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in JW rabbit uterus after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of wild type Androgen receptor (unknown origin) expressed in Freestyle293F cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 6.20nMAssay Description:Agonist activity at wild type Androgen receptor in human LNCaP-hr cells assessed as prostate specific antigen secretion measured after 3 days by enzy...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at wild type Androgen receptor (unknown origin) expressed in human Cos-7 cells co-expressing pGL3-MMTV-luc vector assessed as luc...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [3H] ]5alpha-DHT from mouse androgen receptor expressed in monkey COS7 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKd: 0.182nMAssay Description:Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulinMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Human)
Centre National de la Recherche Scientifique/INSERM/ULP
Curated by ChEMBL
Centre National de la Recherche Scientifique/INSERM/ULP
Curated by ChEMBL
Affinity DataEC50: 4.49E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells by luciferase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at androgen receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-DBD by luciferase r...More data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:Agonist activity at human androgen receptor in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Displacement of [3H]mibolerone from human AR after 3 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.98nMAssay Description:Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transf...More data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity to the human androgen receptor (hAR) in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding affinity to androgen receptor by fluorescence binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro binding affinity at human androgen receptor transfected into COS cells.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:In vitro antagonistic activity against human androgen receptor using cotransfection assay in CV-1 cells; Not active.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonistic activity against human androgen receptor (hAR) expressed in CV-1 cell linesMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Modulation of Androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 0.25nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human Androgen receptor measured by CALUX bioassayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Displacement of fluormone-AL green from GST-tagged androgen receptor LBD (unknown origin) measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+5nMAssay Description:Displacement of [3H]E2 from estrogen receptor in JW rabbit uterus after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:In vitro agonistic activity against human androgen receptor using cotransfection assay in CV-1 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity against Human Androgen receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity against Human Androgen receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Binding affinity to MR (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 0.180nMAssay Description:Agonist activity at human androgen receptor expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.82nMAssay Description:Activity against human androgen receptor expressed in HepG2 cells assessed as luciferase reporter gene activationMore data for this Ligand-Target Pair
Affinity DataIC50: 18.5nMAssay Description:Displacement of androgen fluormone from rat androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.970nMAssay Description:Agonist activity at rat androgen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Competitive inhibition of androgen binding to androgen receptor (unknown origin) by invitrogen polar screen assayMore data for this Ligand-Target Pair