BDBM18140 (2S,3S)-2-amino-3-methylpentanoic acid::Isoleucine::L-[14C]Isoleucine

SMILES CC[C@H](C)[C@H](N)C(O)=O

InChI Key InChIKey=AGPKZVBTJJNPAG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18140   

TargetLarge neutral amino acids transporter small subunit 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | L-[14C]Is...)
Affinity DataIC50: 1.40E+5nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | L-[14C]Is...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetProton-coupled amino acid transporter 1(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | L-[14C]Is...)
Affinity DataKi:  3.70E+7nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed