BDBM18073 (2S)-2-amino-3-phenylpropanoic acid::CHEMBL301523::L-[2,3,4,5,6-3H]phenylalanine::L-phenylalanine::Phenylalanine::US11021454, Compound L-phe
SMILES N[C@@H](Cc1ccccc1)C(O)=O
InChI Key InChIKey=COLNVLDHVKWLRT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 18073
Affinity DataIC50: 8.02E+4nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Nebraska At Kearney
Curated by ChEMBL
University of Nebraska At Kearney
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by sub...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
University of Auckland
Curated by ChEMBL
University of Auckland
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by su...More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMAssay Description:Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Human)
University of Nebraska At Kearney
Curated by ChEMBL
University of Nebraska At Kearney
Curated by ChEMBL
Affinity DataIC50: 6.90E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMAssay Description:Inhibition of human IAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by ...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
University of Auckland
Curated by ChEMBL
University of Auckland
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human TNAP using CDP-star as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IAP by analogous luminescence assayMore data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
University of Auckland
Curated by ChEMBL
University of Auckland
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TNAP by analogous luminescence assayMore data for this Ligand-Target Pair
TargetPhospholipase A-2-activating protein(Human)
Human Biomolecular Research Institute
Curated by ChEMBL
Human Biomolecular Research Institute
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PLAP by analogous luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric...More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Mouse)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 980nMAssay Description:Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brainMore data for this Ligand-Target Pair
TargetLarge neutral amino acids transporter small subunit 1(Rat)
University of Kentucky
Curated by ChEMBL
University of Kentucky
Curated by ChEMBL
Affinity DataKi: 5.50E+4nMAssay Description:Inhibition of LAT1-mediated L-[14C]leucine uptake in Sprague-Dawley rat brain by duel-labeled liquid scintillation countingMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 18073
ITC DataΔG°: -0.717kcal/mole −TΔS°: 2.14kcal/mole ΔH°: -2.87kcal/mole logk: 3
pH: 5.01 T: 25.00°C
pH: 5.01 T: 25.00°C
ITC DataΔG°: -1.24kcal/mole −TΔS°: 1.64kcal/mole ΔH°: -2.87kcal/mole logk: 8
pH: 5.01 T: 25.00°C
pH: 5.01 T: 25.00°C