BDBM17446 (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl N-(2-chloroacetyl)carbamate::CHEMBL424278::TNP-470

SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl

InChI Key InChIKey=QFRQUQINJQBOKG-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 17446   

TargetMethionine aminopeptidase 2(malaria parasite P. falciparum)
Johns Hopkins School of Medicine

LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase(Plasmodium falciparum)
Johns Hopkins School of Medicine

LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 3.00E+5nMAssay Description:Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of MetAP2 after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of MetAP2 (unknown origin) after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMethionine aminopeptidase 2(Human)
The Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataKi:  1nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed