BDBM17325 (2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}-2-(2-methylphenyl)phenyl)formamido]-4-(methylsulfanyl)butanoic acid::ABT-839::CHEMBL29982

SMILES CCCCN(CCC1CCCCC1)Cc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C

InChI Key InChIKey=GAQHYZNOMLXSEA-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 17325   

LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataEC50:  16nMAssay Description:In vitro effective concentration against farnesyltransferase (FT)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Bovine farnesyl transferaseMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataEC50:  16nMAssay Description:Effective concentration against H-ras processing in NIH 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM17325(CHEMBL29982 | (2S)-2-[(4-{[butyl(2-cyclohexylethyl...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed