BDBM17292 (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol::17 beta-Estradiol::17α-ethinylestradiol::17beta-estradiol (E2)::CHEMBL135::CS336::ESTRADIOL::Estradiol-17 alpha::Ovocyclin::US9034854, E2::US9040509, E2::US9422324, E2::US9561238, E2::[2,4,6,7-3H]-17beta-estradiol::[2,4,6,7-3H]-E2::[3H]-estradiol::[3H]]estradiol
SMILES C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O
InChI Key InChIKey=VOXZDWNPVJITMN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 343 hits for monomerid = 17292
Affinity DataIC50: 1.20nMpH: 7.6 T: 2°CAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 7.6 T: 2°CAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated polyvinyltoluene scintillation beads (Amersham) and biot...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 10nM EC50: 0.590nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
Affinity DataIC50: 11nM EC50: 0.840nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 24nM EC50: 0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
Affinity DataIC50: 24nM EC50: 0.0700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetUncharacterized PhzA/B-like protein PA3332(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
D3R/Abbott
D3R/Abbott
Affinity DataKd: 1.90E+4nMAssay Description:CSAR Thermofluor_Method2More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMT: 2°CAssay Description:Estrogen receptor-negative CV-1 kidney cells are maintained in Dulbecco's modified Eagle's medium with 4.5 g/L glucose supplemented with 10% fetal bo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMT: 2°CAssay Description:Estrogen receptor-negative CV-1 kidney cells are maintained in Dulbecco's modified Eagle's medium with 4.5 g/L glucose supplemented with 10% fetal bo...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description:In vitro inhibition of estrogen-stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
Affinity DataEC50: 9.70nMAssay Description:In vitro agonist activity for estrogen receptor beta expressed in COS-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:In vitro agonist activity for estrogen receptor alpha expressed in COS-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataEC50: 0.480nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Binding affinity towards estrogen receptor beta by [3H]17-beta-estradiol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity for estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity for estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0240nMAssay Description:Agonist activity at human ERalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0850nMAssay Description:Agonist activity at human ERbeta expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of fluorescein-labeled estrogen from human recombinant ERbeta by fluorescence polarization based competitive binding affinity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Displacement of fluorescein-labeled estrogen from human recombinant ERalpha by fluorescence polarization based competitive binding affinity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding affinity against human estrogen receptor alpha in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding affinity towards human recombinant Estrogen receptor alpha was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards human recombinant Estrogen receptor beta was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding potency for human ER betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding potency for human ER betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of bindign to recombinant human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of binding to recombinant human estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 0.160nMAssay Description:Agonist activity at human ERalpha expressed in human HEC1 cells assessed as transcriptional activation after 24 hrs by ERE-luciferase reporter gene t...More data for this Ligand-Target Pair
Affinity DataEC50: 0.380nMAssay Description:Agonist activity at human ERbeta expressed in human HEC1 cells assessed as transcriptional activation after 24 hrs by ERE-luciferase reporter gene tr...More data for this Ligand-Target Pair
Affinity DataEC50: 0.00840nMAssay Description:Agonist activity at human ERalpha in human MCF7 cells assessed as progesterone receptor endogenous genes activation after 24 hrs by qPCRMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human ERbeta in human MCF7 cells assessed as otubain 2 endogenous genes activation after 24 hrs by qPCRMore data for this Ligand-Target Pair
Affinity DataIC50: 0.75nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0100nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.18nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0980nMAssay Description:Transcriptional activation of estrogen receptor beta in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0190nMAssay Description:Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35nMAssay Description:Binding affinity to ERalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to ERbetaMore data for this Ligand-Target Pair