BDBM16668 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide::CHEMBL23579::heterocyclic sulfonamide compound 33

SMILES CC(C)(C)C(=O)Nc1nnc(s1)S(N)(=O)=O

InChI Key InChIKey=FNKGYWFCFILCJW-UHFFFAOYSA-N

Data  11 KI

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 16668   

TargetCarbonic anhydrase 4(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of recombinant human CA4 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  0.660nMAssay Description:Inhibition of recombinant human CA2 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of recombinant human CA9 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  9nMAssay Description:Inhibitory effect on human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  10nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Bovine)
University of Namur

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  46nMAssay Description:Inhibitory effect on bovine Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  54nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  63nMAssay Description:Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  110nMAssay Description:Inhibitory effect on human carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
University of Namur

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  185nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM16668(CHEMBL23579 | 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-th...)
Affinity DataKi:  645nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed