BDBM164243 US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 2)

SMILES CC1(C)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12

InChI Key InChIKey=YUDKTFUCCPOVGR-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 164243   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 55nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 55nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 57nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 57nMAssay Description:Inhibition of Mnk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Mnk1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM164243(US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed