BDBM161389 US10124003, Ref. Ex. Compound 3::US10835536, Ex. Comp 2::US10894048, Ex Comp 2::US9108973, 2

SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key InChIKey=KEIPNCCJPRMIAX-UHFFFAOYSA-N

Data  33 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 161389   

TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant FGFR2 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant FGFR3 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 95nMAssay Description:Inhibition of BTK (unknown origin) measured by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 as substrate incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human VEGFR2 (aa805 to 1356 residues) expressed in baculovirus expression system using Poly- (Glu4:Ty...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.60nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human FGFR4 (445 to 753 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human FGFR3 (450 to 758 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.40nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.60nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4.90nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.40nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 0.5nMAssay Description:Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)