BDBM153 (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis(naphthalen-2-ylmethyl)-1,3-diazepan-2-one::CHEMBL33647::XK263

SMILES O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3ccccc3c2)C(=O)N(Cc2ccc3ccccc3c2)[C@@H]1Cc1ccccc1

InChI Key InChIKey=VUYPJDFAKYXJEV-UHFFFAOYSA-N

Data  4 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 153   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Harvard University

Curated by ChEMBL
LigandPNGBDBM153(CHEMBL33647 | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihyd...)
Affinity DataKd:  0.302nMAssay Description:Affinity for HIV ProteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
University of Z£Rich

Curated by ChEMBL
LigandPNGBDBM153(CHEMBL33647 | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihyd...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM153(CHEMBL33647 | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihyd...)
Affinity DataKi:  0.310nM ΔG°:  -13.5kcal/molepH: 5.5 T: 2°CAssay Description:Ki values were determined with recombinant single-chain dimeric HIV protease and a fluorescent substrate. The use of single-chain dimeric protease a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Harvard University

Curated by ChEMBL
LigandPNGBDBM153(CHEMBL33647 | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihyd...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Harvard University

Curated by ChEMBL
LigandPNGBDBM153(CHEMBL33647 | (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihyd...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed