BDBM15239 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine::4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine::CHEMBL274064::SB220025::SB4

SMILES Nc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1

InChI Key InChIKey=VSPFURGQAYMVAN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 15239   

TargetMitogen-activated protein kinase 14(Human)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Rat)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 1.80E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sejong University

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant ERK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Texas At Dallas

LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of amino terminal HA-tagged human RIPK2 transfected in mouse AML12 cells assessed as inhibition of autophosphorylation incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM15239(SB4 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed