BDBM15234 (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate::CHEMBL428496::NSC221019::Wortmannin::Wortmannin, Wm::cid_312145
SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
InChI Key InChIKey=QDLHCMPXEPAAMD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 64 hits for monomerid = 15234
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3 kinase p110alpha/p85-alpha complexMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr in p...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human PI3K p110delta catalytic subunit by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of VPS34 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 4.20nMpH: 7.4 T: 2°CAssay Description:Ptdlns 3-kinase enzyme activity was assayed by its converting Ptdlns(4,5)P2 into PtdIns(3,4,5)P3 in the presence of radioactive ATP. After reaction,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKd: 5.40nMAssay Description:Binding affinity to human PI3Kalpha after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Affinity DataKd: 5.5nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of AX-7503 binding to recombinant Plk1 by Western blotMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataKd: 7.60nMAssay Description:Binding affinity to human PI3Kbeta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human PI3KdeltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Astrazeneca R & D M£Lndal
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human PI3KbetaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human full-length recombinant p110alpha/p85alpha co-expressed in baculovirus expression system using PIP2:PS lipid as substrate incubat...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 11.9nMAssay Description:Inhibition of human recombinant P110alpha/p85alpha using phosphatidyl inositol as substrate after 1 hr by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3 kinase by WmC20 derivatives causing a formation of covalent bond between WmC20 derivatives and the target protein.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3 kinaseMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human p110alpha PI3K fragment by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3K p110beta catalytic subunit by AlphaScreen competition assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 17.6nMAssay Description:Inhibition of PI3K by fluorescence energy transfer assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Human)
Pfizer
Pfizer
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged Plk1 using recombinant protein X as a substrate containing threonine residuesMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against MTORMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant Plk3 assessed as casein substrate phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of AX-7503 binding to recombinant Plk3 expressed in HeLa cells by Western blotMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 55nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human PI3K p110gamma catalytic subunit by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 99nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Targegen
Targegen
Affinity DataIC50: 103nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Binding affinity for DNA dependent protein kinase isolated from HeLa cells; Range is 20-120More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of human recombinant p110 alpha Phosphatidylinositol 3-kinaseMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cell extractMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of Plk3 in human A549 cells assessed as casein substrate phosphorylation by Western blotMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of chicken SmMLCK expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences
Curated by ChEMBL
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of PI4KA catalytic domain (unknown origin) assessed as enzyme residual activity incubated for 60 mins using ATP as substrate by ATP-Glo lu...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of mTOR in rat brain by [3H]-thymidine incorporation based immunoblot assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences
Curated by ChEMBL
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of PI4KB catalytic domain (unknown origin) assessed as enzyme residual activity incubated for 60 mins using ATP as substrate by ATP-Glo lu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PLK1 in the presence of 5uM ATPMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nM ΔG°: -7.86kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
State University of New York-Esf
Curated by ChEMBL
State University of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of PI3K p110alpha/p85alpha (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Human)
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of The Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase (mMLCK)More data for this Ligand-Target Pair
Affinity DataKi: 2.80E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair