BDBM14797 Pyrazole carboxylic ester 20::ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate

SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccccc1Cl

InChI Key InChIKey=XQCKNCFQOJFQFK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14797   

LigandPNGBDBM14797(ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-...)
Affinity DataIC50: 56nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14797(ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-...)
Affinity DataIC50: 19nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14797(ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14797(ethyl 1-(2-chlorophenyl)-3,5-dimethyl-1H-pyrazole-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed