BDBM144315 Gilteritinib::US11512074, Example T-9::US8969336, 547::US8969336, 577
SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1
InChI Key InChIKey=GYQYAJJFPNQOOW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 49 hits for monomerid = 144315
Affinity DataIC50: 0.199nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 6.24nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of Flt3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibition of AXL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of LTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ALK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.15nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 0.187nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human FLT3-ITD mutant expressed in Sf9 insect cells using AGLT peptide and ATP as substrate in presence of [gamma-33P]ATP a...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human FLT3-D835Y mutant expressed in Sf9 insect cells using AGLT peptide and ATP as substrate in presence of [gamma-33P]ATP...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human FLT3-ITD-F691L mutant expressed in Sf9 insect cells using myelin basic protein and ATP as substrate in presence of [g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type FLT3 (unknown origin) phosphorylation in human SEMK2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.33nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.76E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (564 to 993 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibition of N-terminal GST-tagged human AXL (464 to 885 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
TargetTranscription factor ETV6/Tyrosine-protein kinase receptor UFO(Human)
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of AXL (unknown origin) using poly (Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 expressed in human SEMK2 cells assessed as reduction in FLT3 phosphorylation incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of AXL (unknown origin) using poly [Glu, Tyr] 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of FLT3 (unknown origin) using MBP as substrate incubated for 40 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.46nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 7.35nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 7.01nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 6.62nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 5.87nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using Glu/Tyr peptide substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of wild type FLT3 (unknown origin) using Glu/Tyr peptide substrate incubated for 120 mins measured after 40 mins incubation under dark by ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataKi: 1.49E+3nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
University of South Australia
Curated by ChEMBL
University of South Australia
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK7/cyclin H/MAT1 (unknown origin) using HYSPTSPSYSPTSPSYSPTSPSKKKK-O substrate incubated for 120 mins measured after 40 mins incubati...More data for this Ligand-Target Pair