BDBM142256 US8933099, 22::US9951047, Compound (I)

SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12

InChI Key InChIKey=IBHOLSBDZMIPPT-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 142256   

TargetFibroblast growth factor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 4.5nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 3(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 5.40nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR3 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 645nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR4 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 1(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 5.80nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 5.70nMT: 2°CAssay Description:To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 5.10nMT: 2°CAssay Description:To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 6nMT: 2°CAssay Description:To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM142256(US8933099, 22 | US9951047, Compound (I))
Affinity DataIC50: 683nMT: 2°CAssay Description:To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...More data for this Ligand-Target Pair
In DepthDetails
US Patent