BDBM138358 US10278929, Compound 7::US11337935, Compound 7::US8877795, 7
SMILES Cc1n[nH]c(C)c1CCCOc1ccccc1F
InChI Key InChIKey=SIXWAFDHGGAHMK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 138358
Affinity DataIC50: 296nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
Affinity DataIC50: 296nMAssay Description:The FP assay was then adapted for HTS and used to screen a 120,000 member small molecule library for compounds that displaced the FP probe from the T...More data for this Ligand-Target Pair
Affinity DataKd: 320nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
Affinity DataIC50: 296nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 138358
ITC DataΔG°: -8.86kcal/mole −TΔS°: 0.150kcal/mole ΔH°: -9.00kcal/mole logk: 3.16E+6
pH: 7.5 T: 25.00°C
pH: 7.5 T: 25.00°C